Our research

Our research is centered on the design of zwitterion-mediated dearomatization reactions of N-aromatic heteroarenes to access structurally complex and stereodefined N-heterocycles.

Through the strategic use of sulfur ylides, diazo compounds, and allylic sulfonium ylides in combination with Cu(I), Ag, and Pd catalysis, we develop regio- and stereoselective cyclization processes.

We are particularly interested in uncovering the mechanisms of skeletal reorganization, including valence tautomerization and long-range proton transfer, using both experimental and computational approaches.

These studies provide a foundation for the development of novel ring-expansion and ring-contraction methodologies and their application to medicinally relevant heterocyclic scaffolds.